SAN FRANCISCO and HANGZHOU, China, March 10, 2026 — While AI transforms the digital world through cognitive and generative capabilities, a new frontier has emerged: Physical AI — an intelligent system that perceives, reasons about, and acts within the physical world.
Today, Bota introduces SAION AI, the first Physical AI platform tailored for biomanufacturing.
SAION AI isn’t limited to in silico design. Instead, it’s a full-stack Physical AI platform that integrates cognition, orchestration, and closed-loop execution via end-to-end experimentation, continuously optimizing biological discovery and biomanufacturing processes.
SAION AI is structured around a three-layer architecture: Cognition, Orchestration, Execution.
Powered by large language models, the platform unites scientific reasoning with real-world experimental implementation. This architecture enables seamless coordination from understanding biological systems to conducting laboratory experiments, forming a self-optimizing closed loop for biomanufacturing.
Cognition: Multi-Scale Biological Insight
The Cognition Layer is built on data from Bota’s Cell2Cloud Biofoundry, integrating tens of millions of experimental data points, millions of scientific publications and patents, and public biological databases. Combined with leading AI4Science models, SAION AI develops multi-scale understanding across the gene–protein–cell–fermentation continuum, enabling systematic design and data-driven scientific decisions.
Orchestration: Intelligent Research Coordination
The Orchestration Layer centers on the Agent harness orchestration engine, powered by LLM reasoning to coordinate multi-agent collaboration, tool invocation, and end-to-end scientific workflows.
This layer breaks down complex objectives into structured tasks and integrates 316 specialized scientific tools, enabling dynamic routing and automated research workflows with fault tolerance.
Execution: Autonomous Experimental Operation
Through Bota’s proprietary Biological Protocol Language, SAION AI converts experimental designs into standardized instructions that directly control laboratory hardware, feeding real-world data back into the Cognition Layer to enable continuous model improvement and R&D acceleration.
Real-World Performance
SAION AI has demonstrated SOTA performance across multiple life science AI benchmarks, validating its capabilities as an AI Scientist system.
Key Results
- Literature Comprehension: 70.7% on LitQA+SuppQA — outperforming leading general-purpose models
- Sequence Reasoning: 88.2% on SeqQA across DNA, RNA, and protein tasks
- Genetic Engineering: 84.9% on gene editing and cloning benchmarks
- Scientific Discovery: 89.6% on the BAIS-SD benchmark
Real-world validation confirms SAION AI can autonomously complete full research projects — from literature review to wet-lab assembly — with an accuracy rate exceeding 90%.
Toward Autonomous Biomanufacturing
The launch of SAION AI moves biomanufacturing beyond traditional trial-and-error experimentation to an intelligent engineering discipline, where AI and physical laboratories interact to accelerate discovery and industrial scale-up.
SAION AI DEMO
Contact us: bota.pr@bota.bio
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