REHOVOT, Israel, Dec. 17, 2024 — Amai Proteins, a company designing novel proteins, successfully completed the world’s first double-blind, randomized clinical trial evaluating the effects of its hyper-sweet protein, sweelin®, on human blood glucose and insulin levels.
The trial showed sweelin® did not increase blood glucose or insulin levels in healthy adults, even after consuming a quantity with the sweetness equivalent of 75 grams of sugar (glucose).
Amai Proteins conducted this study, exceeding regulatory requirements, to enhance consumer and market confidence in sweelin®’s safety and health benefits. The results provide confirmed evidence of sweelin®’s positive health impact, offering a sugar alternative for consumers seeking to reduce added sugars without compromising taste or well-being.
The study, adhering to Good Clinical Practice (GCP) standards, took place at Tel Aviv Sourasky Medical Center’s Phase 1 Clinical Research Center. Twenty healthy volunteers participated.
Participants made three visits, each time consuming a beverage sweetened with sweelin®, glucose, or stevia in a randomized, double-blind, crossover design. Sweetness levels matched the equivalent of 75 grams of glucose, mirroring an Oral Glucose Tolerance Test (OGTT). Postprandial blood glucose and insulin were monitored for 120 minutes.
All participants completed the study without adverse events or dropouts.
Amai Proteins’ study is the first to confirm that a high dose of sweelin®, also known as ‘serendipity berry sweet protein’, does not affect blood glucose or insulin levels in healthy individuals.
About Amai Proteins
Amai Proteins develops innovative proteins meeting consumer and industry demands. Our initial product, sweelin®, is a zero-calorie sweet protein designed to replace sugar and sugar alternatives in various food and beverages, including soft drinks, fruit juices, dairy products, and more. Our solutions are naturally derived and produced via fermentation. Using our Pro3 platform, Amai Proteins aims for future breakthroughs in meat, plant, and milk proteins.
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For more on sweelin®, visit
For more information:
Dr. Ilan Samish, Founder & CEO, Amai Proteins
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